Understanding the clinical significance of variants associated with hereditary cancer risk requires access to a pooled data resource or network of resources—a “cancer gene variant commons”—incorporating representative, well-characterized genetic data, metadata, and, for some purposes, pathways to case-level data. Several initiatives have invested significant resources into collecting and sharing cancer gene variant data, but further progress hinges on identifying and addressing unresolved policy issues. This commentary provides insights from a modified policy Delphi process involving experts from a range of stakeholder (...) groups involved in the data-sharing ecosystem. In particular, we describe policy issues and options generated by Delphi participants in five domains critical to the development of an effective cancer gene variant commons: incentives, financial sustainability, privacy and security, equity, and data quality. Our intention is to stimulate wider discussion and lay a foundation for further work evaluating policy options more in-depth and mapping them to those who have the power to bring about change. Addressing issues in these five domains will contribute to a cancer gene variant commons that supports better care for at-risk and affected patients, empowers patient communities, and advances research on hereditary cancers. (shrink)

This paper argues against the deductive reconstruction of scientific prediction, that is, against the view that in prediction the predicted event follows deductively from the laws and initial conditions that are the basis of the prediction. The major argument of the paper is intended to show that the deductive reconstruction is an inaccurate reconstruction of actual scientific procedure. Our reason for maintaining that it is inaccurate is that if the deductive reconstruction were an accurate reconstruction, then scientific prediction would be (...) impossible. (shrink)

This book is a philosophical examination of the main stages in our journey from hominid to human. It deals with the nature and origin of language, the self, self-consciousness, and the religious ideal of a return to Eden. It approaches these topics through a philosophical anthropology derived from the later writings of Wittgenstein. The result is an account of our place in nature consistent with both a hard-headed empiricism and a this-worldy but religiously significant mysticism.

AbstractCritics charge that agriculture has reached an unsustainable level of consolidation and expropriation, as exemplified by the supply-chain breakdown of the COVID-19 pandemic. Simultaneously, advocates suggest the current system serves consumers well by keeping prices low and access to choices high. At the center of this debate rests a disagreement over how to compute market power to identify monopolies and oligopolies. We propose a method to study power across different sectors by using Social Network Analysis to analyze key players, the (...) presence of core-periphery structures, and agricultural consolidation. We test our market network approach to power through an analysis of the top ten pork powerhouses. We find that Big Finance is closely tied to Big Ag, and that key players limit the capacity for more peripheral actors, like growers, equipment producers, and regional banks, to engage in the network. We identify system level risk of collapse and suggest pathways for reform. (shrink)

I can’t help but like a book that calls Wittgenstein the greatest philosopher since Kant and then proceeds to show how On Certainty, a manifestly brilliant but understudied book, sheds light on matters under current debate. It is pleasant to see a highly skilled contemporary put texts from the later philosophy under close scrutiny and mine them for insight, and that outside the bounds of familiar Wittgenstein scholarship.

Saul Kripke, among others, reads Wittgenstein’s private-language argument as an inference from the idea of rule following: The concept of a private language is inconsistent, because using language entails following rules, and following rules entails being a member of a community. Kripke expresses the key exegetical claim underlying that reading as follows.

Background Citizen science is increasingly prevalent in the biomedical sciences, including the field of human genomics. Genomic citizen science initiatives present new opportunities to engage individuals in scientific discovery, but they also are provoking new questions regarding who owns the outputs of the research, including intangible ideas and discoveries and tangible writings, tools, technologies, and products. The legal and ethical claims of participants to research outputs become stronger—and also more likely to conflict with those of institution-based researchers and other stakeholders—as (...) participants become more involved, quantitatively and qualitatively, in the research process. It is not yet known, however, how genomic citizen science initiatives are managing the interests of their participants in accessing and controlling research outputs in practice. To help fill this gap, we conducted an in-depth review of relevant policies and practices of U.S.-based genomic citizen science initiatives. Methods We queried the peer-reviewed literature and grey literature to identify 22 genomic citizen science initiatives that satisfied six inclusion criteria. A data collection form was used to capture initiative features, policies, and practices relevant to participants’ access to and control over research outputs. Results This analysis revealed that the genomic citizen science landscape is diverse and includes many initiatives that do not have institutional affiliations. Two trends that are in apparent tension were identified: commercialization and operationalization of a philosophy of openness. While most initiatives supported participants’ access to research outputs, including datasets and published findings, none supported participants’ control over results via intellectual property, licensing, or commercialization rights. However, several initiatives disclaimed their own rights to profit from outputs. Conclusions There are opportunities for citizen science initiatives to incorporate more features that support participants’ access to and control over research outputs, consistent with their specific objectives, operations, and technical capabilities. (shrink)

Saul Kripke, among others, reads Wittgenstein’s private-language argument as an inference from the idea of rule following: The concept of a private language is inconsistent, because using language entails following rules, and following rules entails being a member of a community. Kripke expresses the key exegetical claim underlying that reading as follows.

As biomedical citizen science initiatives become more prevalent, the unique ethical issues that they raise are attracting policy attention. One issue identified as a significant concern is the ethical oversight of bottom-up biomedical citizen science projects that are designed and executed primarily or solely by members of the public. That is because the federal rules that require ethical oversight of research by institutional review boards generally do not apply to such projects, creating what has been called an ethics gap. -/- (...) Working to close this gap, practitioners and scholars have considered new mechanisms of ethical oversight for biomedical citizen science. To date, however, participants’ attitudes about ethics and oversight preferences have not been systematically examined. This information is useful to efforts to develop ethical oversight mechanisms because it provides a basis for evaluating the likely effectiveness of specific features of such mechanisms and their acceptability from the perspective of biomedical citizen scientists. -/- Here, we report data from qualitative interviews with 35 stakeholders in bottom-up biomedical citizen science about their general ethics attitudes and preferences regarding ethical oversight. Interviewees described ten ethical priorities and endorsed oversight mechanisms that are voluntary, community-driven, and offer guidance. Conversely, interviewees rejected mechanisms that are mandatory, hierarchical, and inflexible. Applying these findings, we conclude that expert consultation and community review models appear to align well with ethical priorities and oversight preferences of many biomedical citizen scientists, although local conditions should guide the development and use of mechanisms in specific communities. (shrink)

Wittgenstein's later philosophy and the doctrines of Mahayana Buddhism integral to Zen coincide in a fundamental aspect: for Wittgenstein language has, one might say, a mystical base; and this base is exactly the Buddhist ideal of acting with a mind empty of thought. My aim is to establish and explore this phenomenon. The result should be both a deeper understanding of Wittgenstein and the removal of a philosophical objection to Zen that has troubled some people.

In ‘Wittgenstein and Qualia’ Ned Block argues for the existence of inverted spectra and those ineffable things, qualia. The essence of his discussion is a would-be proof, presented through a series of pictures, of the possible existence of an inverted spectrum. His argument appeals to some remarks by Wittgenstein which, Block holds, commit the former to a certain ‘dangerous scenario’ wherein inverted spectra, and consequently qualia live and breath. I hold that a key premise of this proof is incoherent. Furthermore, (...) Block’s dangerous scenario does not follow from Wittgenstein’s innocent one, as Block believes it does, but rather is in conflict with it. (shrink)

Language Games 2 This chapter provides some background necessary for subsequent discussions by sketching in the idea of a language game, thereby giving a ...

Recent studies challenge the classical view that the origin of animal life was primarily controlled by atmospheric oxygen levels. For example, some modern sponges, representing early‐branching animals, can live under 200 times less oxygen than currently present in the atmosphere – levels commonly thought to have been maintained prior to their origination. Furthermore, it is increasingly argued that the earliest animals, which likely lived in low oxygen environments, played an active role in constructing the well‐oxygenated conditions typical of the modern (...) oceans. Therefore, while oxygen is still relevant to understanding early animal evolution, the relationships between the two might be less straightforward than previously thought. (shrink)

This book deals with some large tracts of Wittgenstein’s writings concerning representation and the mental. Its defining characteristic, and one of its main strengths, is an extensive use of material in the background of Wittgenstein’s Tractatus and Investigations. Stern quotes from and discusses remarks from unpublished manuscripts, including the Big Typescript, little-studied published writings such as the Tractatus notebooks, “Some Remarks on Logical Form,” Philosophical Remarks, Philosophical Grammar, as well as lecture notes by Moore, King and Lee, and others. How (...) much of these writings the book reproduces is suggested by the fact that its appendix, giving the original German of the previously unpublished matter translated in the main text, is eleven small-print pages long; and there are far more quotations from the published part of the corpus. The result is a work in which, for a run of pages, the ratio of quoted material to comment can be as high as one to one ; and in which most pages contain a significant amount of indented quotation. The main justification offered for the wholesale inclusion of this material is that it provides a context that can help determine what problem Wittgenstein was addressing in a given passage from his two main works. Stern’s mastery of that material is impressive, as shown for example in his pellucid outline of Wittgenstein’s philosophical development after 1920. (shrink)

"It's really an impressive thing. . . . It's a great pleasure to read and shows once again that good philosophy can be beautifully written." Roderick Chisholm Brown University.

This book deals with some large tracts of Wittgenstein’s writings concerning representation and the mental. Its defining characteristic, and one of its main strengths, is an extensive use of material in the background of Wittgenstein’s Tractatus and Investigations. Stern quotes from and discusses remarks from unpublished manuscripts, including the Big Typescript, little-studied published writings such as the Tractatus notebooks, “Some Remarks on Logical Form,” Philosophical Remarks, Philosophical Grammar, as well as lecture notes by Moore, King and Lee, and others. How (...) much of these writings the book reproduces is suggested by the fact that its appendix, giving the original German of the previously unpublished matter translated in the main text, is eleven small-print pages long; and there are far more quotations from the published part of the corpus. The result is a work in which, for a run of pages, the ratio of quoted material to comment can be as high as one to one ; and in which most pages contain a significant amount of indented quotation. The main justification offered for the wholesale inclusion of this material is that it provides a context that can help determine what problem Wittgenstein was addressing in a given passage from his two main works. Stern’s mastery of that material is impressive, as shown for example in his pellucid outline of Wittgenstein’s philosophical development after 1920. (shrink)

Background As citizen science continues to grow in popularity, there remains disagreement about what terms should be used to describe citizen science activities and participants. The question of how to self-identify has important ethical, political, and practical implications to the extent that shared language reflects a common ethos and goals and shapes behavior. Biomedical citizen science in particular has come to be associated with terms that reflect its unique activities, concerns, and priorities. To date, however, there is scant evidence regarding (...) how biomedical citizen scientists prefer to describe themselves, their work, and the values that they attach to these terms.Methods In 2018, we conducted semi-structured interviews with 35 biomedical citizen scientists in connection with a larger study to understand ownership preferences. Interview data were analyzed to identify the terms that interviewees used and avoided to describe themselves and their work, as well as the reasons for their preferences.Results Biomedical citizen scientists self-identified using three main terms: citizen scientist, biohacker, and community scientist. However, there was a lack of consensus among interviewees on the appropriateness of each term, two of which prompted conflicting responses. Self-identification preferences were based on personal judgments about whether specific terms convey respect, are provocative, or are broad and inclusive, as well as the desirability of each of these messages.Conclusions The lack of consensus about self-identification preferences in biomedical citizen science reflects the diversity of experiences and goals of individuals participating in this field, as well as different perceptions of the values signaled by and implications of using each term. Heterogeneity of preferences also may signal the parallel development of multiple communities in biomedical citizen science. (shrink)

Volume 10 of the Routledge History of Philosophy presents a historical survey of the central topics in twentieth century Anglo-American philosophy. It chronicles what has been termed the 'linguistic turn' in analytic philosophy and traces the influence the study of language has had on the main problems of philosophy. Each chapter contains an extensive bibliography of the major writings in the field. All the essays present their large and complex topics in a clear and well organised way. At the end, (...) the reader finds a helpful Chronology of the major political, scientific and philosophical events in the Twentieth Century and an extensive Glossary of technical terms. (shrink)

Previous research has demonstrated that speakers adapt individual characteristics of speech production to the social context, for example via phonetic convergence. Studies have measured the impact of social dynamics on convergence in typical speakers, but the impact of individual differences is less well-explored. The present study measures phonetic convergence before and after a cooperative interaction with an undergraduate student by comparing teens with a history of autism spectrum disorder (ASD) and with typical development. Results revealed a small temporal convergence effect (...) for typically developing dyads; in contrast, dyads including autistic teens showed no convergence. Furthermore, the degree of convergence was negatively related to severity of ASD symptomatology and atypical sensory profiles. While social and sensory processing abilities may play a role in phonetic convergence, high covariance between these measures makes it difficult to differentiate their contributions in isolation. (shrink)

_Wittgenstein’s Intentions_, first published in 1993, presents a series of essays dedicated to the great Wittgenstein exegete John Hunter. The problematic topics discussed are identified not only by Wittgenstein’s own philosophical writings, but also by contemporary scholarship: areas of ambiguity, perhaps even confusion, as well as issues which the father of analytic philosophy did not himself address. The difficulties involved in speaking cogently about religious belief, suspicion, consciousness, the nature of the will, the coincidence of our thoughts with reality, and (...) transfinite numbers are all investigated, as well as a variety of other intriguing questions: why can’t a baby pretend to smile? How do I know what I was going to say? Wittgenstein’s Intentions is an invaluable resource for students of Wittgenstein as well as scholars, and opens up a wide horizon of philosophical questioning for those as yet unfamiliar with this style of reasoning. (shrink)

_Wittgenstein’s Intentions_, first published in 1993, presents a series of essays dedicated to the great Wittgenstein exegete John Hunter. The problematic topics discussed are identified not only by Wittgenstein’s own philosophical writings, but also by contemporary scholarship: areas of ambiguity, perhaps even confusion, as well as issues which the father of analytic philosophy did not himself address. The difficulties involved in speaking cogently about religious belief, suspicion, consciousness, the nature of the will, the coincidence of our thoughts with reality, and (...) transfinite numbers are all investigated, as well as a variety of other intriguing questions: why can’t a baby pretend to smile? How do I know what I was going to say? Wittgenstein’s Intentions is an invaluable resource for students of Wittgenstein as well as scholars, and opens up a wide horizon of philosophical questioning for those as yet unfamiliar with this style of reasoning. (shrink)

Wittgenstein’s Intentions , first published in 1993, presents a series of essays dedicated to the great Wittgenstein exegete John Hunter. The problematic topics discussed are identified not only by Wittgenstein’s own philosophical writings, but also by contemporary scholarship: areas of ambiguity, perhaps even confusion, as well as issues which the father of analytic philosophy did not himself address. The difficulties involved in speaking cogently about religious belief, suspicion, consciousness, the nature of the will, the coincidence of our thoughts with reality, (...) and transfinite numbers are all investigated, as well as a variety of other intriguing questions: why can’t a baby pretend to smile? How do I know what I was going to say? Wittgenstein’s Intentions is an invaluable resource for students of Wittgenstein as well as scholars, and opens up a wide horizon of philosophical questioning for those as yet unfamiliar with this style of reasoning. (shrink)

In their most recent book, Evolving Enactivism: Basic Minds Meet Content (MIT 2017), Dan Hutto and Eric Myin claim to give a complete and gapless naturalistic account of cognition, but it comes with a kink. The kink being that content-involving cognition has special properties found nowhere else in nature, making it the case that minds capable of contentful thought differ in kind, in this key respect, from more basic minds. Contra Hutto and Myin, I argue that content-involving practices are themselves (...) simply a further extension of action and do not therefore warrant being called ‘different in kind’ or ‘kinky’. With the help of Ludwig Wittgenstein and John V. Canfield, I show that Enactivism meets the challenge of explaining higher-level cognition; and, contra continuity sceptics, offer ‘a philosophically cogent and empirically respectable account’ of how human minds can emerge from nonhuman minds. (shrink)

In their most recent book, Evolving Enactivism: Basic Minds Meet Content (MIT 2017), Dan Hutto and Eric Myin claim to give a complete and gapless naturalistic account of cognition, but it comes with a kink. The kink being that content-involving cognition has special properties found nowhere else in nature, making it the case that minds capable of contentful thought differ in kind, in this key respect, from more basic minds. Contra Hutto and Myin, I argue that content-involving practices are themselves (...) simply a further extension of action and do not therefore warrant being called ‘different in kind’ or ‘kinky’. With the help of Ludwig Wittgenstein and John V. Canfield, I show that Enactivism meets the challenge of explaining higher-level cognition; and, contra continuity sceptics, offer ‘a philosophically cogent and empirically respectable account’ of how human minds can emerge from nonhuman minds. (shrink)

Background: The magnitude of bullying and harassment among psychiatrists is reportedly high, yet no peer-review published studies addressing this issue could be found. Therefore, it was decided to conduct a pilot study to assess the degree of the problem, the types of bullying/harassment and to provide some insights into the situation.Methods and Principal Findings: Following multiple focus group meetings, a yes/no response type questionnaire was developed to assess the degree and type of bullying and harassment experienced by psychiatrists. Over a (...) 3-month period the questionnaire was administered to a random sample of 60 psychiatrists. 57 out of the 60 psychiatrists reported harassment and bullying. Frequencies of the following response variables are presented in descending order: rumours 40% ; defamation 20% ; passing remarks 20% ; false accusations 15% ; threats 13.3% ; verbal abuse 13.3% ; unjustified complaints 13.3% ; promotion blocked 13.3% ; humiliation 13% ; bad reference given 10% ; credentials questioned 8.3% ; physical attacks 5% ; termination 5% ; derogatory remarks 1.7% and 1.7% were subjected to personal work. As a result of being subjected to harassment, 66.7% of the psychiatrists did not take any action, whereas 33.3% confronted the person they believed responsible. Asked whether the bullying and harassment caused distress, 18.3% of the psychiatrists did not report any effect, 30% reported mild distress, 40% moderate distress and severe distress was reported by 11.7%.Conclusions: It was concluded that the magnitude of bullying and harassment among psychiatrists may be quite high, as evidenced by this pilot study. There is a need for extensive systematic studies on this subject and to establish strategies to prevent and address this issue at a national and regulatory level. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.1 (2003) 121-122 [Access article in PDF] Harold Tarrant. Plato's First Interpreters. Ithaca, NY: Cornell University Press, 2000. Pp. viii + 263. Cloth, $55.00. This is Tarrant's third book on the ancient Platonist tradition, following his Scepticism or Platonism? (1985) and Thrasyllan Platonism (1993). In those earlier volumes his focus was on the first centuries bc and ad. Here his scope is much (...) wider. Stating that "Platonic interpretation is today at a crossroads," he has written a book that explores "ancient attempts to wrestle with this corpus," with the ultimate objective "to encourage a fresh, almost primitive reading of Plato himself" (vii).He begins engagingly by confronting the ancients with questions any modern reader of Plato must ask: What kind of text is this? Are there doctrines here? Where do I look for Plato's doctrines? The second part of his book is a historical survey, taking us from Plato, the early Academy and Aristotle, through the Hellenistic and early Roman Imperial period, and concluding with the principal Neoplatonist interpreters. In the third and longest part, he focuses on the interpretation of specific dialogues, giving most space to the Gorgias and Theaetetus, but also dealing in particular detail with the Meno, Parmenides, and Philebus. Something is said about every dialogue, but Tarrant writes only briefly about such major works as the Republic and Timaeus. He explains his selectivity (not very convincingly) as due to his wish to "discuss issues of meta-interpretation, with emphasis on the period before Plotinus" (198).Taking his book as a whole, one realizes that few strands of modern interpretation were not prefigured to quite a large extent in antiquity. The two most obvious exceptions are the chronological and developmental approach (Early, Middle, and Late), at present under strong attack from some quarters, and the theological, numerological, and allegorical readings practiced by Neoplatonists. Plato's ancient interpreters were doctrinal unitarians, but they implicitly anticipated our tendency to distinguish "Socratic dialogues," which some of them called "gymnastic" and "inquisitive," from such "canonical" works as the Phaedo,Republic, Symposium, and Timaeus, to which they applied the labels "dogmatic" and "expository." And they recognized that both types of characteristics could be found in the same dialogue, as in the Meno and Theaetetus. Plato himself, they proposed, spoke primarily through the voices of Socrates, Timaeus, and the Eleatic and Athenian strangers; but other characters, such as Pausanias in the Symposium, or Protagoras in the dialogue of that name, utter thoughts with some philosophical value. In explaining difficult passages of one dialogue, they would typically refer to passages from other parts of the corpus. An especially intriguing instance is the strategy of the Anonymous Commentator on the Theaetetus, who reads the Meno into the dialogue on which he is officially commenting.Ancient scholars, just like ourselves, asked questions about the unifying themes of complex dialogues. Hence the sub-titles given to certain works: "On the soul" for the Phaedo, and "On justice" for the Republic, etc. For Olympiodorus (whose commentary on the Gorgias Tarrant has recently co-edited [Leiden, 1998]), earlier interpreters have seriously erred by giving too limited an account of that dialogue's scope. It is not, he says, simply about rhetoric, nor about justice and injustice; nor is its theme the divine demiurge (as some Neoplatonists had strangely proposed, on the basis of the concluding myth). Rather, the subject of the Gorgias is "the ethical principles that lead to constitutional well-being" (125). [End Page 121] However, Olympiodorus's eminently "sensible" reading (as Tarrant calls it) is deeply embedded in the Neoplatonic contrast between the "purificatory virtues" of the Phaedo and the "constitutional virtues" of Republic4.Strong or weak scepticism, esotericism, unwritten doctrines, spurious versus genuine, a canon of central dialogues, dramatic considerations, and the philosophical importance or non-importance of the dialogues' prologues—all of these are interpretive approaches that Tarrant surveys in this immensely learned book, and all of them continue to resonate for us. Modern scholars, who emphasize the literary and philosophical unity of each dialogue, are walking... (shrink)

During recent years we have seen and assisted at a significantly increased number of twin births. The main reason for this increase in the frequency of twin births is the increasing number of so called “induced pregnancies”, whether through hormonal stimulation or artificial insemination techniques.It is well known1 that twins have high mortality and morbidity rates during the perinatal and the following period. The characteristics of conception and pregnancy can determine the development of several pathologies, including prematurity and intrauterine growth (...) retardation, …. (shrink)

The philosophy of Epictetus, a freed slave in the Roman Empire, has been profoundly influential on Western thought: it offers not only stimulating ideas but practical guidance in living one's life. A. A. Long, a leading scholar of later ancient philosophy, gives the definitive presentation of the thought of Epictetus for a broad readership. Long's fresh and vivid translations of a selection of the best of Epictetus' discourses show that his ideas are as valuable and striking today as they were (...) amost two thousand years ago. This is a book for anyone interested in what we can learn from ancient philosophy about how to live our lives. (shrink)